This study investigates the challenges in teaching grammar to English as a Foreign Language (EFL) students. More specifically, it focuses on grammar challenges caused by the interference of the students’ native languages, teaching strategies and the classroom environment. The research includes 100 EFL students at two different English Departments at Herat University. A questionnaire is adopted to test the challenges in the three different areas. Statistical tests are applied to check if the challenges are perceived to affect by students’ grammar skill. The findings show that students’ learning is significantly influenced by three key factors: language interference, teaching strategies, and classroom environment. Most students reported challenges with understanding English, emphasized the importance of effective teaching strategis, and noted that classroom conditions impact their focus. Implications on native language and both instructional and environmental improvements are regarded as crucial for enhancing learning outcomes.