The Indian Knowledge System (IKS) represents an extensive collection of indigenous insights that haveinfluenced numerous disciplines, including mathematics, medicine, astronomy, architecture,metallurgy, linguistics, and philosophy. Grounded in the Vedas, Upanishads, and other ancientwritings, IKS provides comprehensive and sustainable approaches that continue to hold significance intoday's scientific landscape. This paper investigates the interdisciplinary connections betweentraditional Indian knowledge and modern science, focusing on its relevance in areas such as ModernScience, Vedic mathematics and computational sciences, along with environmental sustainability andtechnological progress.The research underscores the significance of incorporating Indian Knowledge Systems (IKS) into formaleducational and research frameworks to promote innovation, sustainability, and comprehensivedevelopment. It further explores the contributions of artificial intelligence, biotechnology, andquantum physics in affirming and advancing the principles of ancient Indian wisdom. By employingan analytical and comparative methodology, this study illustrates how the amalgamation of traditionalknowledge with contemporary scientific practices can yield holistic solutions to pressing global issuesrelated to health, ecology, and human welfare. Additionally, the paper reviews current policies andacademic structures that support IKS and proposes methods for its broader integration into mainstreamknowledge systems. The findings indicate that the synergy between IKS and modern science is crucialfor driving innovation, achieving sustainable development, and enhancing global well-being