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Anatomy-to-tract mapping infers white matter pathways without diffusion streamline propagation

Authors: Tan, Yee Fan; Huynh, Khoi; Liu, Siyuan; Phan, Raphael C.-W.; Ting, Chee-Ming; Yap, Pew-Thian;

Anatomy-to-tract mapping infers white matter pathways without diffusion streamline propagation

Abstract

Abstract Diffusion tractography, a cornerstone of white matter mapping, relies on point-to-point streamline propagation, a process often limited by the signal-to-noise ratio and spatioangular resolution of diffusion MRI (dMRI). Here, we present Anatomy-to-Tract Mapping (ATM), a framework that generates bundle-specific streamlines directly from T1-weighted MRI without requiring orientation field estimation, voxelwise segmentation, or streamline propagation. ATM leverages the high quality and minimal distortion of anatomical MRI and learns from paired T1w and tractogram data to synthesize anatomically plausible, subject-specific streamlines. This anatomy-driven approach addresses complex configurations such as crossing, kissing, and bending fibers, providing robust bundle reconstructions. Using the TractoInferno dataset with 30 white matter bundles, we evaluate ATM against diffusion-based methods, including MRtrix probabilistic tracking with BundleSeg and SCIL atlas warping. ATM demonstrates strong performance across multiple metrics, including bundle similarity, volume coverage, angular correlation, and geometric fidelity.

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
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gold
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