The COVID-19 pandemic has revealed significant gender-based disparities in health outcomes, with mounting evidence suggesting that men are more vulnerable to severe forms of the disease and its long-term complications. This brief review highlights the biological, behavioral, and psychosocial factors contributing to men’s disproportionate burden during the pandemic. Biologically, men exhibit weaker immune responses and higher expression of viral entry receptors such as ACE2 and TMPRSS2, which may partly explain higher hospitalization and mortality rates. Hormonal factors, particularly low testosterone levels and lack of estrogenic protection, have also been implicated. In addition, men tend to engage in higher-risk behaviors, delay medical care, and experience more pronounced economic and psychological impacts due to occupational and social disruptions. Recent studies also raise concerns about the effects of SARS-CoV-2 on male reproductive health, including impaired sperm quality and hormonal imbalance. Despite these risks, health policies and clinical responses have largely remained gender-neutral, overlooking the need for targeted interventions. This letter argues for increased research attention, sex-disaggregated data, and gender-sensitive healthcare strategies to improve health outcomes for men during and beyond the COVID-19 crisis.