The Phoenix dactylifera, commonly known as the date palm, is a widely cultivated plant recognized for its nutritional and medicinal properties. It has gained attention for its potential role in cosmetic applications. Date seeds contain abundant phytochemicals that may function as potent phytomedicines. In this study, topical application of Saidi date seed methanolic extract (20.0%, 15.0%, and 10.0% v/v) and pure seed oil to the dorsal skin of four male rabbits demonstrated significant hair growth effects. Throughout the evaluation period (days 7, 14, and 21), the pure seed oil produced the greatest increase in hair length (2.64 mm), exceedingly even the positive control (2.0% minoxidil, 1.962 mm). The methanolic extract induced concentration-dependent growth, with values of 2.295 mm, 2.01 mm, and 1.92 mm for 20.0%, 15.0%, and 10.0%, respectively. Hair mass measurements on day 22 corroborated these findings, with the highest weight recorded for the oil (0.347 g), followed by the positive control. In conclusion, the study reveals the potent hair growth activity of Saidi seed oil and methanolic extract, highlighting their potential as natural alternatives for hair loss treatment.