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ZENODO
Article . 2025
License: CC BY
Data sources: ZENODO
ZENODO
Article . 2025
License: CC BY
Data sources: Datacite
ZENODO
Article . 2025
License: CC BY
Data sources: Datacite
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Deintenzifikace inzulinoterapie u diabetes mellitus 2. typu v klinické praxi

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2025 Czech Publisher:Zenodo
Authors: Novodvorsky, Peter; Zizka, Ondrej; Haluzik, Martin;

doi: 10.5281/zenodo.15682871 , 10.5281/zenodo.15682870

Deintenzifikace inzulinoterapie u diabetes mellitus 2. typu v klinické praxi

Abstract

Potreba simplifikace (deintenzifikace) intenzifikovaneho inzulinoveho rezimu (IIR) je u pacientu s diabetes mellitus 2. typu dusledkem casteho zahajovani teto terapie v minulosti, kdy nebyly k dispozici jine alternativy. Deintenzifikace je v soucasne dobe umoznena dostupnosti fixnich kombinaci bazalniho inzulinu a agonistu receptoru glukagonu podobneho peptidu 1 (giukagon-iike peptide 1, GLP-1) (iGlarLixi, IDegLira). Studie IDEAL prokazala, ze deintenzifikace IIR prechodem na iGlarLixi je u pacientu s diabetes mellitus 2. typu ucinnou a bezpecnou moznosti simplifikace terapie, ktera poskytuje porovnatelnou glykemickou kompenzaci, benefity redukce telesne hmotnosti, snizeni mnozstvi inzulinovych injekci a celkove denni davky inzulinu, zlepseni hodnot pri kontinualnim monitorovani glykemie (continuous glucose monitoring, CGM), a to bez zvyseneho rizika hypoglykemie a s vyssi spokojenosti pacientu s lecbou.

Podpořeno projektem Národní institut pro výzkum metabolických a kardiovaskulárních onemocnění (Program EXCELES, ID: LX22NPO5104) – Financováno Evropskou unií – Next Generation EU.

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Keywords

iGlarLixi (Suliqua), diabetes mellitus 2. typu, fixni kombinace bazalniho inzulinu a agonisty receptoru GLP-1 (FRC), inzulinoterapie, deintenzifikace, IDegLira (Xultophy)

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
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