The present work encompasses the novel drug design synthesis of 1H 2,4,5 triphenyl imidazole derivatives. The possible improvements in the activity can be further achieved by slide modification in the substituent on the basic imidazole nucleus. Imidazole derivative by ACD Lab Chemsketch and biological activities was predicted using various computational software such as Molinspiration, Admet SAR and Pass. The designed compound having required physiochemical properties, drug-likeness and obeying Lipinski rule of five were selected for molecular docking studies using chimera autodock vina. The designed ligand was docked with target protein 1TUB. All novel drug of 2,4,5 triphenyl imidazole derivative with a potent drug of Dacarbazine. 2,4,5 triphenyl imidazole are synthesized by refluxing benzil, ammonium acetate and benzaldehyde at 100oC for 5-24 hours. Keywords: Insilico design, Triphenyl imidazole, 1TUB, Molecular docking.