This dataset contains supporting files for the reproducibility analyses presented in the paper:"Cohort-level analysis of human de novo mutations points to drivers of clonal expansion in spermatogonia." The files include de novo mutation counts, enrichment results, gene annotations, expression data, and precomputed model outputs. They are designed to be used alongside the Jupyter notebooks provided in the accompanying GitHub repository:https://github.com/mikemoldovan/CES_Discovery/ These resources enable users to reproduce the key findings of the study and explore the analyses in detail.