The etiological structure and peculiarities of clinical and epidemiological manifestations of acute intestinal infections in hospitalised children are studied. A retrospective study of the case histories of 2479 children hospitalised with the clinic of acute intestinal infection was carried out. All patients underwent standard laboratory examination, including clinical, biochemical, instrumental diagnostic methods, bacteriological and molecular-biological studies to verify the causative agent. The epidemiological anamnesis of all children was clarified, and the frequency of background and concomitant diseases was studied. The diagnosis of intestinal infection was verified in 925 children (38%). Bacterial intestinal infections were detected in 610 (65 % of the transcripts).