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image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao ZENODOarrow_drop_down
image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
ZENODO
Dataset . 2025
License: CC BY
Data sources: ZENODO
ZENODO
Dataset . 2025
License: CC BY
Data sources: Datacite
ZENODO
Dataset . 2025
License: CC BY
Data sources: Datacite
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Spatially Resolved Joint Profiling of Transcriptome and Translatome at Molecular Level

Research datakeyboard_double_arrow_right Dataset 06 Jun 2025Publisher:Zenodo
Authors: Ren, Jie; Ye, Lingyuan; Zhang, Lingxuan; Yao, Muchen; Cheng, Chen; Zhu, Keyao; Zhao, Xiaomei; +8 Authors

doi: 10.5281/zenodo.15607494 , 10.5281/zenodo.15607495

Spatially Resolved Joint Profiling of Transcriptome and Translatome at Molecular Level

Abstract

This dataset contains spatially resolved transcriptomics (transcriptome) and translatomics (translatome) data generated using STATES (Spatially-resolved Transcriptomics And Translatomics Employed Simultaneously), a multiplexed 3D in situ sequencing technology. STATES enables joint profiling of transcriptome and translatome at molecular resolution, revealing spatiotemporal dynamics of gene expression and translation efficiency (TE) across cellular and tissue contexts. Data includes: Cell line (HeLa): Time-course data under endoplasmic reticulum (ER) stress, capturing transcriptional and translational dynamics. Mouse brain tissue: Spatially mapped TE patterns across cell types, anatomical regions, and subcellular compartments. Formats: Processed data in Zarr (for efficient storage/access of spatial arrays) and H5AD (AnnData format for single-cell/spatial omics). Json file represents cell shape polygons of mouse brain tissues. Csv file represents UMAP cell embeddings of mouse brain tissues.

Keywords

multiplexed three-dimensional in situ sequencing, Spatially-resolved Transcriptomics And Translatomics

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average