Ayurveda is a branch of the science of well-being. The vast majority of Ayurvedic medication is derived from plants. Ayurveda's specific field of agada tantra (toxicology) emphasizes the many forms of poisoning and how to treat them. Various therapy modalities are employed in the management of distinct poisoning instances. One of the modalities called agada (antidote) is made by combining several anti-poisonous plants. Panchashirisha Agada is one of the important herbal medicines for Keeta Visha (insect bite) that the Shushruta Samhita mentions. It has broad-spectrum medicinal properties. The five parts of this plant are the fruit, root, bark, flower, and leaves. In Bruhattrayee (the major Ayurvedic treatises), several formulations of Shirisha with varying ways of administration have been recorded for the treatment of various poisons.