This abstract outline the development and validation of UV-visible spectroscopic method for quantification and forced degradation of lumateperone in pharmaceutical dosage forms. Method development involves optimizing chromatographic conditions, while validation ensures the method’s accuracy, precision, linearity, and robustness. Lumateperone is a medication used to manage and treat schizophrenia and other neuropsychiatric disorders. It is a second-generation atypical antipsychotic medication that exhibits a novel mechanism of action. This activity describes the indications, mechanism of action, and administration of lumateperone as a valuable treatment of schizophrenia.