ABSTRACT Both bacteria and fungi have the ability to significantly influence global biogeochemical cycles. Both positive and negative interactions can occur between bacteria and fungi. Numerous microorganisms, mostly bacteria but also fungi, viruses, and archaea, make up the human body's microbiota. A large network of both positive and negative interactions between fungi and bacteria contributes to both human gain and damage. While an amount of data has been published on bacterial relationships, far less data is known on the interactions of bacteria with another component of the fungal community. Therefore, our goal is to examine and evaluate the biological relationships that exist between fungi and bacteria in the human body. According to the findings of our review, all polymicrobial interactions may be categorized as synergism, predisposition, microbial interference, and addition, regardless of whether they are solely bacterial, fungal, or cross-kingdom.