Powered by OpenAIRE graph
Found an issue? Give us feedback
ZENODOarrow_drop_down
ZENODO
Article . 2025
License: CC BY
Data sources: Datacite
ZENODO
Article . 2025
License: CC BY
Data sources: Datacite
versions View all 2 versions
addClaim

Method Development and Validation of Efavirenz as A Dosage Form by UV Spectrophotometer

Authors: K. D. Mane*, M. K. Patil, P. B. Sutar, Dr. S. K. Mohite;

Method Development and Validation of Efavirenz as A Dosage Form by UV Spectrophotometer

Abstract

The main aim of the present study is to develop a simple, sensitive, specific, spectrophotometric method developed for the detection of Efavirenz in bulk drug as a dosage form. The optimum condition for the analysis of the drug was established. The wavelength (λmax) of the Efavirenz was found to be 265nm. The proposed method can be performed by using UV-Visible spectrophotometry using 0.1N NaOH as solvent. Various analytical factors, including linearity, precision, accuracy, Limits of quantitation (LOQ) and detection (LOD) were determined in accordance with ICH recommendations. This method shows the linearity of 5 to 35μg/ml. The response function gave a correlation coefficient R2 = 0.9992. Limit of detection was discovered to be 5.735μg/ml and the Limit of quantification was determined as the lowest concentration was discovered to be 19.12μg/ml. The proposed method will be suitable for the examination of Efavirenz in bulk. The proposed technique is applicable to drug analysis in routine quality control & method proves to be more economical than the other standard methods.

Keywords

Efavirenz, Spectrophotometry, Linearity, Accuracy, Quality Control

  • BIP!
    Impact byBIP!
    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    0
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Average
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Average
Powered by OpenAIRE graph
Found an issue? Give us feedback
selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
Upload OA version
Are you the author of this publication? Upload your Open Access version to Zenodo!
It’s fast and easy, just two clicks!