
The main aim of the present study is to develop a simple, sensitive, specific, spectrophotometric method developed for the detection of Efavirenz in bulk drug as a dosage form. The optimum condition for the analysis of the drug was established. The wavelength (λmax) of the Efavirenz was found to be 265nm. The proposed method can be performed by using UV-Visible spectrophotometry using 0.1N NaOH as solvent. Various analytical factors, including linearity, precision, accuracy, Limits of quantitation (LOQ) and detection (LOD) were determined in accordance with ICH recommendations. This method shows the linearity of 5 to 35μg/ml. The response function gave a correlation coefficient R2 = 0.9992. Limit of detection was discovered to be 5.735μg/ml and the Limit of quantification was determined as the lowest concentration was discovered to be 19.12μg/ml. The proposed method will be suitable for the examination of Efavirenz in bulk. The proposed technique is applicable to drug analysis in routine quality control & method proves to be more economical than the other standard methods.
Efavirenz, Spectrophotometry, Linearity, Accuracy, Quality Control
Efavirenz, Spectrophotometry, Linearity, Accuracy, Quality Control
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