The global surge in lifestyle diseases such as coronary artery disease, diabetes, and obesity calls for comprehensive, sustainable interventions beyond pharmaceutical dependence. Chronobiology has brought attention to the vital role of the biological clock in disease prevention and reversal. Simultaneously, spiritual frameworks like the daily Murli discourses of the Brahma Kumaris offer structured lifestyle education harmonizing spiritual, mental, emotional, and physical health. This paper explores Murli as a resource of modern medicine aligned with circadian rhythms for the prevention and regression of lifestyle disorders. Drawing upon recent findings, including the Mount Abu Open Heart Trial, this study positions Murli-centered living—encompassing early rising, Rajyoga meditation, a plant-based sattvic diet, and value-based living—as a powerful, evidence-backed lifestyle intervention.