Male infertility is a growing concern worldwide, with immune-related factors contributing significantly to its prevalence. One important diagnostic tool for identifying immune-based infertility is the Mixed Antiglobulin Reaction test. This test detects the presence of anti-sperm antibodies that can affect sperm function and fertility. The Mixed Antiglobulin Reaction test has become an essential tool in diagnosing male infertility caused by immune factors and in guiding clinicians to develop effective treatment plans. Immunological infertility occurs when the immune system mistakenly targets sperm as foreign entities, impairing their ability to fertilize the egg. This condition can cause difficulties in conception even when other reproductive factors appear normal. By identifying anti-sperm antibodies, the test enables healthcare professionals to choose appropriate treatments, including the use of immunosuppressive therapies, sperm washing techniques, or assisted reproductive technologies such as intrauterine insemination or in vitro fertilization.