The study aimed to formulate and evaluate colon-specific compression-coated core tablets of Metronidazole for treating intestinal amoebiasis, focusing on improved efficacy, reduced dosing frequency, and enhanced patient compliance. Core tablets were prepared using wet granulation method with PVP K-30 as a binder and sodium starch glycolate as a disintegrant. Compression-coated tablets utilized varying ratios of chitosan and Carbopol 934P polymers. Granules were assessed for physical properties like angle of repose, bulk density, compressibility index, etc. Tablets underwent tests for weight variation, hardness, friability, drug content, and in-vitro drug release. Results showed polymer ratios significantly influenced Metronidazole release, with F1 and F2 formulations meeting prescribed limits and exhibiting good appearance.