This policy white paper, developed under the EU4Health-funded CAN.HEAL project (101080009), offers a strategic analysis of the integration of Next-Generation Sequencing (NGS) and Public Health Genomics (PHG) in European healthcare systems. Drawing from expert consensus and peer-reviewed research, the document identifies disparities in implementation across Europe, and outlines key policy, infrastructure, and data governance challenges. It provides actionable recommendations for EU and national policymakers, healthcare providers, researchers, and patient advocacy groups. The paper emphasizes the need for harmonized regulatory frameworks, workforce development, equitable access to genomic services, and cross-border data interoperability, positioning genomics as a cornerstone of future precision healthcare in Europe.