Transferosomes is a proprietary drug delivery technology, an artificial vesicle suitable for controlled and potentially targeted drug delivery. Transferosomes have recently been introduced, which are capable of delivery of low as well as high molecular weight drugs. This offers several potential advantages like avoidance of first pass metabolism, predictable and extended duration of activity, minimizing undesirable side effects, utility of short half life drugs, improving physiological and pharmacological response and have been applied to increases the efficiency of the material transfer across the intact skin. Composition of transferosomes contains edge activators and phospholipids. Transferosomes penetrate the stratum corneum by intracellular route or the Tran cellular route by the generation of “osmotic gradient”. The characterization of Transferosomes is similar to that of other vesicles like liposomes, noisome and micelle.