Acute lymphoblastic leukemia (ALL) in children often leads to gastrointestinal complications such as diarrhea due to chemotherapy, radiation, and immunotherapy treatments. These therapies damage the gut mucosa, disrupt gut microbiota, and increase susceptibility to infections, exacerbating diarrhea. Effective management strategies, including rehydration, probiotics, and selective antibiotics, are essential to mitigate symptoms and prevent complications like dehydration and malnutrition. Long-term approaches focusing on monitoring gut health and dietary interventions, such as prebiotics and probiotics, are crucial for improving the quality of life and supporting recovery in children with ALL.