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ZENODO
Dataset . 2025
License: CC BY
Data sources: ZENODO
ZENODO
Dataset . 2025
License: CC BY
Data sources: Datacite
ZENODO
Dataset . 2025
License: CC BY
Data sources: Datacite
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Bimodal genomic approach predicting Semaphorin 7A (SEMA7A) as prognostic biomarker in adrenocortical carcinoma

Authors: Dhall, Anjali; Taniyama, Daiki; Elloumi, Fathi; Luna, Augustin; Varma, Sudhir; Kumar, Suresh; Escobedo, Lauren; +6 Authors

Bimodal genomic approach predicting Semaphorin 7A (SEMA7A) as prognostic biomarker in adrenocortical carcinoma

Abstract

Bimodal Gene Detection using Gaussian Mixture Modeling in Tumor Expression Data. Description: This project provides an R-based analytical pipeline designed to identify genes with bimodal expression patterns across tumor samples. Bimodal expression may indicate tumor heterogeneity, subtype-specific gene regulation, or clinically relevant expression shifts. The pipeline uses: Gaussian Mixture Modeling (GMM) to fit two-component distributions for each gene Hartigan’s Dip Test to test for non-unimodality Required R Packages: readxl tidyverse diptest nor1mix You can install the required packages in R using: install.packages(c("readxl", "tidyverse", "diptest", "nor1mix")) How to Run: Ensure the expression matrix file named Gene_Expression.csv is placed in the same directory as the script. Then run: Rscript code.R This will generate the ranked list and plots for downstream analysis or interpretation.

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average