Abstract Rare genetic disorders often manifest with systemic and oral health challenges, including periodontal complications. Adolescents affected by these disorders face unique challenges due to ongoing physiological changes, hormonal shifts, and the psychosocial impact of their conditions. This review explores the periodontal implications of rare genetic disorders during adolescence, highlighting the pathophysiology, clinical manifestations, and management strategies. Emphasis is placed on the importance of early diagnosis, interdisciplinary care, and tailored preventive measures to mitigate periodontal risks and enhance overall oral health.