Abstract Oral health is an essential but often overlooked component of general health. Emerging evidence reveals a profound bidirectional relationship between oral health and systemic diseases, such as cardiovascular disease, diabetes, adverse pregnancy outcomes, respiratory infections, and rheumatoid arthritis. This review delves into the underlying mechanisms connecting oral and systemic health, emphasizing the roles of chronic inflammation, microbial translocation, and immune dysregulation. Preventive strategies, including oral hygiene practices, professional care, and lifestyle modifications, are pivotal in mitigating systemic risks. Additionally, advancements in salivary diagnostics, microbiome research, and integrated healthcare models promise to revolutionize the management of oral-systemic health. Recognizing the mouth as a gateway to systemic well-being underscores the importance of holistic healthcare approaches to enhance both oral and overall health outcomes.