Women as nation builders, have made numerous contributions in various aspects of the nation’s economy, therefore their well-being is of paramount importance. This study examined the relationship among religion, income and well-being of employed women in South-East, Nigeria. Simple random sampling technique was used to select two hundred and ten (210) working women in South-East, Nigeria. Attitude Toward Religion Scale (ATRS) and Psychological Well-being Scales (PWBS) were filled by the participants while income was measured with the demographic data. Data collected were analyzed using Pearson’s product moment correlation and multiple regression at 0.05 level of significance. Five hypotheses were tested and the results revealed significant relationships among the variables of study. A significant joint influence of religion and income was found accounting for 88.2% variance in psychological well-being. Religion and income also had relative influence on well-being but income had greater influence. Age did not have significant moderating influence on well-being. It was recommended that management should endeavor to improve the take-home package of working women while women themselves should be more committed to religious practices since it enhances their well-being and that further researches should be carried out on religion and well-being across different religious groups in Nigeria.