The ASAP Collaborative Research Network (CRN) launched in 2020 to galvanize the global research communityon Parkinson’s disease (PD). This program embeds open science principles to accelerate discoveries and improveoutcomes, foster collaboration, generate resources, and share data assets for informing the path to a cure within aglobal research network. OUR APPROACH • Encourage diverse perspectives and open discourse to support high-risk, ambitious projects, reshaping howscience in the Parkinson’s field is conducted.• Reinvigorate the research pipeline to identify new targets and pathways for translational studies andcommercialization. FOCUS AREAS From 2020 to 2024, the CRN supported 35 multidisciplinary, international teams across 14 countries, addressingthree priority research areas: 1. PD Functional Genomics2. Neuro-Immune Interactions3. Circuitry and Brain-Body Interactions As we enter our fifth year of the CRN, we want to evaluate our success in the following overarching principles ofthe initiative.