Around the world, antimicrobial resistance (AMR) is posing a significant threat to numerous lives. It is therefore essential to develop effective techniques to counteract the ill effects of AMR. These challenges are being met with efforts from drug discovery teams by synthesizing novel antimicrobials with improved activity against the resistant microorganisms. However, of late, there has been a great emphasis on the synthesis of pharmaceuticals by environment friendly and green approaches. Chromene is a privileged structure exhibiting varied biological activities including antimicrobial activity. This article reviews various green syntheses methods for the preparation of chromene derivatives as potential antimicrobial agents. These syntheses include processes including various catalysts such as ionic liquids, nanoparticles, biocatalysts and other catalysts derived from agriculture, animal husbandry, horticulture and poultry. The development of green syntheses methods for a privilege structure like chromenes offers a much-needed boost in the fight against AMR by providing chemical leads without impacting the environment.