The PYSOLO Project Management and Quality Handbook is meant to serve as a reference document for the day-to-day management of the project, in order to provide the consortium with a comprehensive overview of the most important internal management procedures, capitalising on EUCORE extensive experience in the management of EU funded projects. The present version of the Handbook constitutes a simplified version for publication; the full version of the Handbook, containing the detailed description of the consortium boards and their composition, together with the envisaged approaches for the overall project management (including the handling of IPR personal data), is made available to the PYSOLO consortium only on the project shared repository, as, due to its contents, it is a sensitive document.