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Dissection of core promoter syntax through single nucleotide resolution modeling of transcription initiation (CLIPNET data)

Authors: He, Adam Y.; Danko, Charles;

Dissection of core promoter syntax through single nucleotide resolution modeling of transcription initiation (CLIPNET data)

Abstract

This contains data necessary to reproduce the figures in the CLIPNET paper (preprint here) as well as processed data used to train and evaluate CLIPNET. To preserve subdirectory structure, we've packaged the data into tar archives. Please refer to the README documents in our manuscript GitHub repo for more details on file contents: https://github.com/Danko-Lab/clipnet_paper/ Pretrained CLIPNET models are archived separately at DOI 10.5281/zenodo.10408622 V5: Fixed bug in calculation of profile attribution scores causing them to be off by a factor of exactly 500. Genome-wide DeepSHAP tracks & TF-MoDISco tracks have been accordingly updated. I have not updated the individual examples, as these can be quickly fixed by simply multiplying by 500 when plotting. Additionally, I have uploaded profile and quantity motif calls, which contain genome-wide seqlet annotations. The columns in these files are [chrom, start, end, peak_idx, motif_annotation]. V4: Uploaded individual bigWigs. These have been lifted over using CrossMap from the original hg19 (GSE110638) to hg38 and RPM normalized. V3: Final version prior to journal submission. Don't recall exact details of what's changed. V2: evaluation_metrics.tar.gz and evaluation_data.tar.gz have been replaced. Previously, we benchmarked the models by treating each peak in each individual as a separate data point. Here, we instead predicted from the reference genome and compared against the averaged bigWigs.

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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average