Abstract: Research is considered as the most authentic way of knowledge derivation which might be applied either in science (scientific research) or industry (industrial research) or both to solve the global issues. To achieve the optimum version of reproducible and authentic knowledge, several approaches are being applied such as interdisciplinary, multidisciplinary and transdisciplinary research approaches. Multidisciplinary and interdisciplinary research approaches are widely used techniques where the experts of different disciplines work together whereas in the Transdisciplinary research approach, an individual or team is expert of almost all disciplines and apply a holistic approach enforcing you to think outside the box. Current article is an In-Depth Analysis of all these approaches, understanding the key differences and how to apply a transdisciplinary approach for a more authentic conclusion.