Abstract: Coronary Artery Disease (CAD) remains the leading cause of morbidity and mortality worldwide, significantly impacting patients' quality of life. As frontline healthcare providers, nurses play a crucial role in the prevention, management, and rehabilitation of patients with CAD. This review explores the etiology, pathophysiology, clinical manifestations, diagnostic approaches, nursing management, and patient education strategies for CAD. A comprehensive nursing approach, incorporating risk factor modification, medication adherence, lifestyle changes, and psychological support, is essential for optimizing patient outcomes. The article also discusses recent advancements in nursing interventions, cardiac rehabilitation, and evidence-based practices that enhance the quality of care for CAD patients.