Abstract: Polypharmacy, the concurrent use of multiple medications, is a growing concern among the elderly due to its association with adverse drug reactions, medication non-adherence, and increased healthcare costs. Nurses play a critical role in identifying, preventing, and managing polypharmacy-related issues. This article explores the prevalence, risk factors, consequences, and nursing strategies for addressing polypharmacy in the elderly population. Emphasis is placed on nursing assessment, medication reconciliation, patient education, and interprofessional collaboration. Understanding these aspects can help improve patient safety and healthcare outcomes.