Medicated chewing gum (MCG) has emerged as an innovative and patient-friendly drug delivery system, offering both local and systemic therapeutic effects. It provides a convenient, non-invasive, and water-free method of drug administration, making it highly suitable for individuals with swallowing difficulties and that requiring on-the-go medication. MCG formulations have been developed for a wide range of therapeutic applications, including dental care, pain management, smoking cessation, and weight control. The ability of MCGs to enhance drug bioavailability through buccal absorption while avoiding first-pass metabolism makes them a promising alternative to conventional oral dosage forms. Additionally, they can be formulated for controlled, immediate, or extended drug release, improving therapeutic outcomes. This review provides a comprehensive analysis of the formulation, mechanism of drug release, pharmacokinetics, advantages, limitations, and applications of MCGs in pharmaceutical and nutraceutical therapy. The growing interest in this dosage form highlights its potential as a novel and effective drug delivery system, with future advancements expected to further optimize its efficacy and acceptance in modern medicine.