############################################################################################################### # Epigenome-wide association study of pregnancy exposure to green space and placental DNA methylation ############################################################################################################### #NOTE: In this study the regression coefficients are reported as the difference in DNA methylation by IQR of continuous green space exposures to green space (NDVI 100m, NDVI 300m, NDVI 500, Distance GS and Use GS) or by exposure group of the categorical variables (Visual GS) (ie. visual access to greenery equal to or more than half of the living room window vs. less than half). EWASpla_NDVI100m_main.txt: NDVI 100 m during pregnancy genome-wide DNA methylation summarized results (Main) EWASpla_NDVI300m_main.txt: NDVI 300 m during pregnancy genome-wide DNA methylation summarized results (Main) EWASpla_NDVI500m_main.txt: NDVI 00 m during pregnancy genome-wide DNA methylation summarized results (Main) EWASpla_UseGS_main.txt: Use of green space during pregnancy genome-wide DNA methylation summarized results (Main) EWASpla_VisualGS_12w_main.txt: Visual access to green space during pregnancy (12w) genome-wide DNA methylation summarized results (Main) EWASpla_VisualGS_32w_main.txt: Visual access to green space during pregnancy (32w) genome-wide DNA methylation summarized results (Main) #------- #Headers #------- -probeID: CpG name-BETA: Coefficient of the association-SE: Standard error of the association-P_VAL: P-value of the association-padj.bonf: Significant (yes/no) after Bonferroni (BN) correction (P-value < 7.2 x 10-8) -chr: Chromosome -pos: Position refers to Genome Research Consortium human genome build 37 (GRCh37)/UCSC human genome 19 (hg19) -Relation_to_Island: Island: located in a CpG island; S_Shore: 0-2 kb downstream (3') from a CpG island; N_Shore: 0-2 kb upstream (5')from a CpG island; OpenSea: the rest of the genome; N_Shelf: 2-4 kb upstream (5') from the CpG island; S_Shelf: 2-4 kb downstream (3') from the CpG island.-UCSC_RefGene_Group: Gene location -UCSC_RefGene_Name: Annotated gene using the Illumina database