Objective: The research work aims to demonstrate the potential of this microsponge gel as an effective treatment for severe acute pain with improved drug delivery and therapeutic outcomes. The research work involves the formulation and characterization of a Dexketoprofen Trometamol loaded microsponge gel for the severe acute pain. Microsponges are introduced as a promising drug delivery system due to their ability to provide sustained drug release and improved skin permeation with increased stability and its use in a microsponge gel formulation is hypothesized to improve its efficacy. Method: Microsponge loaded with Dexketoprofen trometamol were successfully formulated by quasi-emulsion solvent diffusion method. The dosage form was formulated by the organic phase containing drug and solvent (ethanol) with polymer (1-5% w/v) and outer phase containing water with surfactant (PVA) (0.1-1%w/v). The internal phase was added drop-wise to external phase with high speed continuous stirring that formulate porous microsponge after evaporation. The polymers used were ethyl cellulose and Eudragit L100. Result: Thus total 8 formulations were prepared with different polymer, surfactant and solvent combinations. It was observed that the among 4 formulation containing ethyl cellulose as polymer the formulation F2 showed lowest particle size of 09µm and greater drug content (59.14%), larger drug entrapment efficiency (60.85%) and a better spreadability of 9.20g.cm/sec, and formulation F6 showed least particle size(12µm) and better drug content, drug entrapment efficiency ( 61.24%, 59.10%, respectively), and a better spreadability of 9.12g.cm/sec. among both F2 and F6, F2 could be considered as a better formulation.Conclusion: In this study it was founded that microsponge had a greater stability among wide temperature range and shows better drug loading capacity and good spreadability that might be used for sustained release formulation.