The main aim of this research is formulate allopurinol loaded Transethosomal gel in which Transethosomes of allopurinol were composed of different concentration of soya lecithin, Cholesterol, tween-80 and solvent by using the cold method. Transethosomes were characterized of entrapment efficient, SEM (scanning electron microscopy), FTIR (Fourier transform infrared spectroscopy), In-vitro drug release as well as stability. Then the allopurinol Transethosomes were incorporated into the gel and evaluated for pH, wash ability, spread ability, Viscosity and stability. SEM studies showed that the Transethosomes are spherical in shape. FTIR result showed that there is no interaction of drug and excipients during the formulation of Transethosomes. The cumulative percentage of drug release of Transethosomes is 82.5 percent, entrapment efficiency is 85.2 percent the ph of the Transethosomal gel is 6.4, the viscosity of the Transethosomal gel is 3000cp. this rsearch result showed that the allopurinol loaded Transethosomal gel can be potentially used for transdermal delivery.