Abstract: Introduction: Prostate cancer is the most common cancer in men and the second leading cause of cancer deaths in men. It affects middle-aged and older men and usually has an indolent but progressive clinical course. Aim of the study: This study aims to: Assess quality of sexual life of patients with prostate cancer. Design: descriptive exploratory design was used for the present study. Sample: quota sample). Setting; The study was conducted in Oncology Department Unit at two setting; Menoufia University Hospital and Shebien-Elkoom Teaching Hospital in Menoufia Gogernorate. Instrument: Prostatic cancer interviewing questionnaire consisted of 3 parts. Part I: Socio-demographic interviewing questionnaire Part II: Prostate cancer interviewing questionnaire (medical history). Part III Quality of sexual life interviewing questionnaire including physical, psychological, behavioral and social parts. Results: percentage of the total quality of sexual life score indicated that more than half of the studied sample (54.0%) had low quality of sexual life, while one-fifth (42.0%) of them had moderate quality of sexual life. There was a significant positive correlation between the studied sample total quality of sexual life and their satisfaction with sexual life (p ≤ 0.05). Conclusion: more than half of the study participants experienced poor quality of life (sexual, psychological, physiological and social QOL domains). Recommendations In light of the study findings, the following recommendations are proposed: Improving the men’s knowledge concerning prostate cancer toward stress management and lifestyle modifications. The need for a hospital based support group as psychologists and consultants for the men with prostate cancer to improve their psychological indexes such as quality of life. Keywords: Quality of Sexual Life, Prostate Cancer. Title: Quality of Sexual Life for Patients with Prostate Cancer Author: Dr. Hanaa El-Sayed Shahin, Mohamed Abd-Allah Abd-Almonaem, Prof. Dalal Mohamed Khalil Eshra, Prof. Inass Kassem Aly Kassem International Journal of Novel Research in Healthcare and Nursing ISSN 2394-7330 Vol. 12, Issue 1, January 2025 - April 2025 Page No: 111-129 Novelty Journals Website: www.noveltyjournals.com Published Date: 01-March-2025 DOI: https://doi.org/10.5281/zenodo.14949652 Paper Download Link (Source) https://www.noveltyjournals.com/upload/paper/Quality%20of%20Sexual%20Life%20for%20Patients%20-01032025-1.pdf