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BRAINscape

Authors: Ruhela, Vivek; Basilio Cieza Huaman; Zikun Yang; Giuseppe Tosto;
Abstract

BRAINscape: A Comprehensive Multi-Omics Analysis Tool Overview BRAINscape is an R package designed for integrative multi-omics analysis, specifically developed for the MU-BRAIN dataset, a multiethnic RNAseq dataset. The package facilitates stratified eQTL mapping and Differential Expression Analysis, providing a user-friendly framework for researchers to explore genetic and transcriptomic associations. Features - eQTL Analysis: Supports cis and trans eQTL mapping.- Differential Expression Analysis: Uses DESeq2 for robust transcriptomic profiling.- Interactive Data Exploration: Shiny-based web interface for data visualization.- Supports Ethnicity-Specific Analysis: Users can filter results by Hispanic and Non-Hispanic Whites (NHW) groups.- Advanced Visualization: - Manhattan Plots for eQTL results. - Volcano Plots for Differential Expression Analysis.

Related Organizations
Keywords

Genetic Variation/genetics, MU-BRAIN, Alzheimer, GWAS, DESeq2, eQTL

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    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
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    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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    impulse
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average