The severity of seasonal influenza infection and illness heavily depend on the immune and general health status of infected people. However, flu-related complications are observed mainly with elderly patients and people with comorbidities, including diabetes mellitus. Patients with diabetes are at increased risk of influenza infection. Vaccination against influenza is one of the effective preventive measures for reducing and controlling flu. Influenza vaccine use is low among the population and increasing the vaccination rate among individuals with diabetes must be a priority in the coming years.