
Introducción: El antígeno carbohidratado 15.3 es un antígeno relacionado con la mucina epitelial polimórfica, marcador del cáncer de mama. Niveles superiores de este a las 30 U/mL están vinculados con una supervivencia global menor. Objetivo: Describir el empleo del antígeno carbohidratado 15.3 en el seguimiento de pacientes con cáncer de mama luego de ser tratadas con quimioterapia en el Hospital Vladimir Ilich Lenin de Holguín en el período comprendido entre marzo y noviembre del 2020. Métodos: Se realizó un estudio observacional descriptivo, transversal y retrospectivo, de un universo de 78 pacientes, se seleccionaron 30 a través de un muestreo no probabilístico intencional. Las variables analizadas en correspondencia con la investigación fueron: edad, valor del CA15.3 antes y después del tratamiento, hallazgos de recidivas en la tomografía axial computarizada. Se utilizó la estadística descriptiva. Resultados: El intervalo de edad que predominó se encontraba entre 62 y 70 años (33,3%). Antes de la aplicación de la quimioterapia los valores séricos de antígeno carbohidratado 15.3 fueron normales (66,6%) y posterior al tratamiento fueron detectadas cifras elevadas de este marcador tumoral (63,3%). Con respecto a los hallazgos de la tomografía axial computarizada fueron negativos a la presencia de recidivas (53,3%). Conclusiones: Los valores del antígeno carbohidratado 15.3 utilizados en las pacientes de la tercera edad con cáncer de mama fueron normales; sin embargo, luego del tratamiento con quimioterapia se elevaron, sin hallazgos significativos en la tomografía axial computarizada.
Introduction: Carbohydrate antigen 15.3 is related to polymorphic epithelial mucin, a marker of breast cancer. Levels higher than 30 U / mL are associated with lower overall survival. Objective: To describe the use of carbohydrate antigen 15.3 in the follow-up of patients with breast cancer, after being treated with chemotherapy, at Vladimir Ilich Lenin Hospital in Holguín, from March to November 2020. Methods: A descriptive, cross-sectional retrospective observational study was carried out in a universe of 78 patients, from which 30 were selected through an intentional non-probabilistic sampling. The variables analyzed in correspondence with the research were: age, CA15.3 value before and after treatment, as well as findings of recurrences on computerized axial tomography. Descriptive statistic was used. Results: The predominant age interval was between 62 and 70 years (33.3%). Before chemotherapy, the serum levels of carbohydrate antigen 15.3 were normal (66.6%), and after treatment high levels of this tumor marker were detected (63.3%). Regarding the findings of the computerized axial tomography, they were negative for the presence of recurrences (53.3%). Conclusions: The values of carbohydrate antigen 15.3 used in the elderly patients with breast cancer were normal; however, after chemotherapy treatment they increased, with no significant findings on computerized axial tomography.
Biomarcadores de Tumor, Estudios de Seguimiento, Neoplasias de la Mama
Biomarcadores de Tumor, Estudios de Seguimiento, Neoplasias de la Mama
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