The project iKaaS, “intelligent Knowledge as a Service” is part of the European Program Horizon 2020 – EUJ2014 of the European Union. The aim is the development of innovative Cloud technologies to fulfil the new challenges surged with the large amount of data steaming from the Internet of Things, facing the requirements from business, industrial and social applications. In this sense iKaaS aims to integrate these three technological fields to develop a new platform that leverage the advantages of IoT such as object virtualization and real time processing, Big Data analysis to build knowledge while offering their capabilities through a multi-cloud environment. Platform features will be demonstrated through Smart City applications to promote the self-management of health and security of citizens and improving information systems and data analysis to achieve a more intelligent city, focused in areas like epidemiological surveillance. The results of the project are tested in three use cases, including the so-called “Environmental health service in Madrid City (Spain)”, which includes transport and mobility.