Abstract The interpretation and reading of literary and artistic works in order to understand the work or the intention of the artist, in the form of hermeneutic knowledge, is regarded as one of the first manifestations of the audience's encounter with the work. The process of understanding the work of art depends on various elements such as the lifestyle and artistic background of the artist, the popular art style of his time, the intellectual and philosophical movements in the lifetime of the artist and the audience, and the intellectual and aesthetic mentality of the creator and appreciation of the work. Because of the two-way complexities that exist in the process of creating and understanding artistic and literary works, various intellectual approaches from different spectrums of thinkers, writers and philosophers have focused and written articles on this dynamic process. Meanwhile, appreciation and interpretation are considered as two basic tools for the interpreter in the fields of reading, perception and understanding. The current research, which is of a fundamental type, has been conducted through the library and online research through an analytical-descriptive method and with a historical and comparative approach, and was written in order to answer this fundamental question: "What common and distinctive elements does reading works of painting and animation have as two media among common artists?” The case study of this research was done by focusing on paintings and animation works by Salvador Dali and Ali Akbar Sadeghi, and the finding is that the most appropriate hermeneutic reading of these works should be a mixture of interpreting the artist's central intention and a special interpretation by the audience, through decoding which is formed from the hidden symbols in the work. Keywords: hermeneutics, painting, animation, Salvador Dali, Ali Akbar Sadeghi.