This paper titled countering gender challenges in knowledge production in Nigeria, West Africa, x-rays the challenges militating against gender educational production in Nigeria, West Africa. The study adopted qualitative methodology of research; which includes;non-participant observation, oral interview, literary materials on gender equality. Gender feminist theory was adopted for the theoretical framework, using Charlotte Whitton in Christ quote which maintains that, “whatever women do they must do twice as well as men to be thought half as good, luckily this is not difficult”. The author mentioned more than twenty-one factors militating against gender knowledge production and discussed about five in details. Five recommendations is given for possible adaptation. The author concluded with Robbins quote which says ‘Women, do two thirds of the work, however receive ten percent of the world’s income and own one per cent of the means of production, which implies the huge gap in gender equality all over the world, Nigeria inclusive. Keywords: Challenges, Education, Gender, Knowledge, Production