One way of improving traffic performance are dynamic traffic control systems using modern Intelligent Transport Systems (ITS) tools also on rural roads. Among ITS systems are those informing drivers about travel time (Travel Time Information System) using variable message signs or information channels such as the Internet, GSM, and GPS to reroute traffic. To assess their performance, in terms of reliability in the evaluation of safety all the elements of the network has been taken into account. In this framework, the present research work reports an evaluation of road safety on the road sections included in the Travel Time Information System (TTIS) on the example of Intelligent Traffic Control System of the Podhale Region (ISSRRP) in Poland. The assessment of road safety has been carried out considering the network level, calibrating separately crash prediction models for classes of intersection and links. The specification of Regional and National road sections allowed the comparison of the safety on alternative road sections with lower geometric parameters included in TTIS.