This dataset/supportive materials, originally published as supplementary material for the associated article, contains comprehensive data to support the study. The study was conducted with to achieve the following objectives: Identify available tools and guidelines for assessing medication appropriateness and aiding in the deprescribing of potentially inappropriate medications (PIMs). Evaluate the development and validation methods employed for explicit and mixed tools and guidelines. Develop a comprehensive thematic list of medications extracted from identified explicit and mixed tools and guidelines, categorized based on the target populations and rationale for evaluating medication use. Describe the available level of evidence supporting the medications or medication classes included in the identified tools and guidelines. It is structured as follows: SuppInfo_search strategy: Detailed search strategies for each database, offering transparency and replicability for the study's literature search process.SuppInfo_Metadata: A detailed methodology for compiling lists of medications tailored to specific target populations. It includes a thematic classification of medication appropriateness to facilitate the interpretation of SuppInfo_compiled medication list for different target populations.SuppInfo_Reasons for the exclusion: A comprehensive list of publications excluded from the final synthesis, accompanied by clear reasons for their exclusion.SuppInfo_risk of bias assessment: Evaluations of critical appraisals for included studies. Systematic reviews were assessed using the JBI Critical Appraisal Checklist, while guidelines were evaluated with the AGREE II checklist.SuppInfo_compiled medication list for different target populations: A thematically classified list of medications, organized based on their appropriateness for different target groups.