The Deliverable D6.4 - Report on deployed and launched IRISCC interoperability framework with guidance documentation for service developers provides a high-level overview of the IRISCC Interoperability Framework, deployed under Work Package 6 (WP6) of the IRISCC project. The interoperability framework is built on the D4Science Virtual Research Environment (VRE). It supports collaborative research by offering a unified platform for data management, computational tools, and reproducibility. At its core, the framework is accessible through the IRISCC VRE Gateway, a web portal available at https://iriscc.d4science.org. This gateway acts as a centralised access point for all services and resources, providing functionalities such as a Shared Workspace for collaborative file management, tailored Virtual Labs (VLabs) for the integration of research demonstrator tools, and user-friendly tools like Jupyter Notebooks, RStudio, Shiny Apps, and the Cloud Computing Platform (CCP) to facilitate advanced computational workflows. The framework is supported by a robust Identity and Access Management (IAM) service that ensures secure and federated access through widely adopted protocols. Integration with external systems, such as the EGI Check-in service, enables cross-institutional collaboration, while secure access controls ensure consistency and compliance across all services. The report also provides guidance for service developers, such as the IRISCC WP4 Demonstrators, on effectively leveraging the framework. Developers can utilise advanced tools to deploy customised services, containerised applications, and automated workflows. By relying on the framework’s infrastructure for critical functions such as authentication, authorisation, resource monitoring, and scalability, developers can focus on innovation and the creation of impactful solutions. Furthermore, the framework simplifies integration with external resources, enhances collaboration, and reduces operational complexity.