Abstract In the modern world, allergies rank among the most common adverse reactions to medications and food products. However, certain reactions occur without the formation of antibodies, yet they present with similar clinical symptoms. This phenomenon is known as "pseudoallergy" or non-allergic anaphylaxis. Like true allergies, pseudoallergies involve various subtypes and activation mechanisms. Regardless of the underlying pathway, these reactions ultimately result in the release of mediators, particularly histamine. This article examines the pathomechanisms of pseudoallergies and highlights current approaches to their pharmacological management.