This dataset is a key output of the Transform4Europe Research and Innovation (T4ERI) project, encompassing data and results generated through the collaboration of multiple work packages (WP2, WP3, WP4). It reflects the project's aim to foster digital and environmental transformation for smart, sustainable, and inclusive regions across Europe. The dataset contains: Data from WP2: Includes insights into the development of a joint research and innovation agenda, mapping research expertise, and the feasibility of joint research centers. Data from WP3: Focused on strategies for talent development, leadership in science, and creating supportive frameworks for early-career researchers. Data from WP4: Related to public engagement, science communication, and strategies for mainstreaming open science practices. Together, this dataset provides a comprehensive view of the collaborative efforts across T4E universities and their stakeholders, aimed at advancing knowledge and innovation ecosystems, addressing societal challenges, and promoting sustainability and inclusivity across Europe.