Nanosuspensions represent a promising formulation strategy to enhance the solubility and bioavailability of poorly soluble drugs, particularly those classified under Biopharmaceutical Classification System (BCS) Class II. This class encompasses drugs that exhibit high permeability but low solubility, posing significant challenges for effective therapeutic delivery. Nanosuspensions involve the reduction of drug particle size to the nanometer scale, leading to an increase in surface area and dissolution rate. This review explores the methodologies employed in the preparation of nanosuspensions, including wet milling, high-pressure homogenization, and precipitation techniques. Additionally, the physicochemical properties, stability considerations, and potential applications of nanosuspensions in drug delivery systems are discussed. The review highlights the advantages of this approach, such as improved solubility, enhanced drug stability, and the potential for targeted delivery. Furthermore, recent advancements and regulatory considerations in the development of nanosuspension formulations are examined, emphasizing their role in overcoming the solubility challenges faced by BCS Class II drugs. Keywords : Nanosuspension ,Solubility enhancement, BCS Class II drugs, Drug delivery, High permeability, Poorly soluble drugs, Particle size reduction, Wet milling, High -pressure homogenization, Precipitation Techniques, Bioavailability, Physicochemical properties, Stability, Targeted delivery, Formulation development