Abstract The global economy faces complex challenges impacting growth, development, and stability. Rising inflation, supply chain disruptions, and trade conflicts strain international markets. Technological advancements and automation transform industries while widening income inequality exacerbates social tensions. Moreover, climate change and geopolitical uncertainties pose long-term risks, threatening sustainable economic progress. In an era marked by profound global economic challenges, ranging from inflation and income inequality to climate change and geopolitical uncertainty, the need for innovative and adaptive management practices is more pressing than ever. Invariably, the parable of the shrewd manager in Luke 16:1-8 offers a compelling lens through which modern economic leaders can reflect on resourcefulness and strategic thinking in times of crisis. This biblical narrative highlights the importance of shrewdness, which connotes practical wisdom, foresight, and agility in navigating complex and uncertain economic landscapes. This paper offers an exegesis of Luke 16:1-8 in the parable of the shrewd manager, through a qualitative approach, explores the concept of shrewdness in management in Luke 16:1-8, discusses the Challenges of the Global Economy, thereby reflecting on the intersection of Shrewdness in Lk 16:1-8 and Global Economic Challenges. This paper maintains that strategic foresight and adaptability are crucial to navigating economic challenges; resourcefulness and leveraging networks would provide access to essential resources and markets in a global economy while balancing pragmatism with ethics and future-oriented thinking vital for individuals and organizations in addressing economic uncertainties today. Keywords: Shrewdness, Management, Luke 16:1-8 and Global Economic