Common bean (Phaseolus vulgaris L.) is an important legume that is highly consumed in Latin America and other countries as a part of feeding. It provides proteins, carbohydrates, vitamins, fiber and a wide range of minerals, which are essential in human nutrition. Determining the nutrient removal values on seeds is crucial to better adjust fertilization rates, increase nutrient use efficiency and nutritional quality. Therefore, a field experiment was conducted in northern Sinaloa in order to investigate the response of common bean variety Azufrado Reyna to different NPK fertilization rates on seed mineral content and nutrient harvest index values. The experiment was arranged as a randomized complete block design with three replicates. Based on the results, fertilization rates only influenced on the total mean protein content, phosphorus and iron. The total nutrient removal values were K>Ca>P>Mg and Fe>Zn>Mn>B>. While nutrient harvest index values indicated that N, P, Fe and Zn exhibited higher degree of mobility to grain compared to the rest of nutrients. These parameters could represent a good trait in terms of nutritional quality for common bean varieties, also, serve as reference values to precisely estimate nutrient removal from soil.